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Molecular Formula: C17H19ClN2S
HCL Molecular Weight: 355.3
CAS No.: 69-09-0
| Name | chloropromazine hydrochloride |
| Synonyms | CP HEBANIL LARGACTIL KLORPROMEX Chlorpromazine HCL LABOTEST-BB LT00452986 lorproMazine hydrochloride ChlorpoMazine Hydrochloride Chlorpromazine hydrochloride chloropromazine hydrochloride Chlorpromazine Hydrochloride (200 mg) ChlorproMazine hydrochloride(Largactil) 2-CHLORO-10-(3-DIMETHYLAMINOPROPYL)PHENOTHIAZINE HCL 2-CHLORO-10-[3′-(DIMETHYLAMINO)PROPYL]PHENOTHIAZINE, HCL 2-CHLORO-N,N-DIMETHYL-10H-PHENOTHIAZINE-10-PROPANAMINE, HCL 2-CHLORO-10-(3-DIMETHYLAMINOPROPYL)PHENOTHIAZINE HYDROCHLORIDE 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine 2-Chloro-10-[3-(dimethylamino)-1-propyl]phenothiazine Hydrochloride 2-Chloro-N,N-diMethyl-10H-phenothiazine-10-propanaMine Hydrochloride [3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-dimethylamine hydrochloride Chlorpromazine hydrochloride,2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil |
| CAS | 69-09-0 |
| EINECS | 200-701-3 |
| InChI | InChI=1/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H |
| Molecular Formula | C17H20Cl2N2S |
| Molar Mass | 355.33 |
| Density | 1.2221 (estimate) |
| Melting Point | 192-196°C |
| Flash Point | 9℃ |
| Water Solubility | >=10 g/100 mL at 24 ºC |
| Solubility | DMSO 71 mg/mL Water 71 mg/mL Ethanol 71 mg/mL |
| Appearance | Powder/Solution |
| Color | White to off-white or clear colorless |
| Merck | 14,2185 |
| BRN | 3779989 |
| PH | pH (50g/L, 25℃) : 4.0～5.0 |
| Storage Condition | 2-8°C |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. Air and light sesnsitive. |
| Sensitive | Sensitive to light and humidity |
| MDL | MFCD00012654 |
| Physical and Chemical Properties | melting point 192-196°C water-soluble> = 10g/100 mL at 24°C White or opalescent crystalline powder. Melting point 179-180 °c (194-196 °c). Soluble in water, ethanol, chloroform, insoluble in ether, benzene. With hygroscopicity, 5% aqueous solution with pH value of 4-5. Slightly odorous, extremely bitter. This product is easy to oxidize, in the air or sunlight gradient to red-brown.dangerous goods Mark T + risk category code 25-26 safety instructions 28-36/37-45 dangerous goods transport number UN 2811 6.1/PG 1 WGK Germany 3 RTECS SO1750000 F 3-10-21 |
| Use | This product is a representative drug in the drug of the drug. On the central nervous system, small doses have a stabilizing effect, large doses of continuous use of antipsychotic effect, this product inhibits the hypothalamus temperature regulation center, so that the body temperature with the ambient temperature rise and fall, with other drugs, to reduce the body temperature to normal body temperature, decreased metabolism, called artificial hibernation. It is mainly used for antipsychotics, strengthening the role of hypnotics, anesthetics, analgesics and anticonvulsants. And can be used for the Vomit and intractable hiccup of vomiting and cause artificial hibernation. |
| In vitro study | Chlorpromazine affects microipsc (mIPSCs) by decreasing binding (Kon) and increasing binding disengagement (Koff) of GABAARs. Chlorpromazine regulates the activation of the TRPA1 current in a potential-dependent manner, resulting in an increase in the probability of blocking at positive potentials and opening at negative potentials. |
| In vivo study | Chlorpromazine down-regulates various T-cell-derived lymphokines (IL-2,IFN-γ,IL-4, tumor necrosis factor, and GM-CSF) independently the generation and upregulation of IL-10 secretion in an in vivo model of acute superantigen-driven immune activation. Chlorpromazine mediates SEB-driven Chlorpromazin secretion, accompanied by an enhanced accumulation of IL-10 mRNA. Chlorpromazine protects against lethality in mice, normal or adrenal and guinea pigs against LPS and suppresses serum levels of tumor necrosis factor. When administered 30 minutes before LPS induction, at the same time, or 10 minutes after PS induction, Chlorpromazine prevents lipopolysaccharide lethality, administration after 30 minutes of LPS induction is ineffective. In actinomycin D-induced sensitized LPS mice, Chlorpromazine significantly inhibited the lethality and hepatotoxicity of LPS. Chlorpromazine protects brain tissue from anoxia-induced irreversible loss of synaptic transmission in rats. In) rats, Chlorpromazine also significantly delayed the onset of hypoxia-induced diffuse depression. |
| Risk Codes | R25 – Toxic if swallowed R26 – Very Toxic by inhalation R39/23/24/25 – R23/24/25 – Toxic by inhalation, in contact with skin and if swallowed. R11 – Highly Flammable |
| Safety Description | S28 – After contact with skin, wash immediately with plenty of soap-suds. S36/37 – Wear suitable protective clothing and gloves. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S16 – Keep away from sources of ignition. |
| UN IDs | UN 2811 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | SO1750000 |
| FLUKA BRAND F CODES | 3-10-21 |
| TSCA | Yes |
| HS Code | 29173980 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 orally in rats: 225 mg/kg (Goldenthal) |
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