Levodopa

Molecular Formula: C9H11NO4

Molecular Weight: 197.2

CAS No.: 59-92-7

Names and Identifiers

Name	L-DOPA
Synonyms	L-DOPA Levodopa H-Tyr(3-OH)-OH L-3-Hydroxytyrosine 3-HYDROXY-L-TYROSINE 3-Hydroxy-L-tyrosine 3,4-L-DIHYDROXYPHENYLALANINE 3,4-DIHYDROXY-L-PHENYLALANINE 3,4-Dihydroxyphenyl-L-alanine L-3-(3,4-Dihydroxyphenyl)alanine 3,4-Dihydroxyphenylalanine(form2) 3-(3,4-DIHYDROXYPHENYL)-L-ALANINE L-DOPA 3,4-L-Dihydroxyphenylalanine BETA-(3,4-DIHYDROXYPHENYL)-L-ALANINE 2-amino-3-(3,4-dihydroxyphenyl)propanoicacid
CAS	59-92-7
EINECS	200-445-2
InChI	InChI=1/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
InChIKey	WTDRDQBEARUVNC-LURJTMIESA-N

59-92-7 – Physico-chemical Properties

Molecular Formula	C9H11NO4
Molar Mass	197.19
Density	1.3075 (rough estimate)
Melting Point	276-278 °C (lit.)
Boling Point	334.28°C (rough estimate)
Specific Rotation(α)	-11.7 º (c=5.3, 1N HCl)
Flash Point	225°C
Water Solubility	Slightly soluble in water, dilute hydrochloric acid and formic acid. Insoluble in ethanol.
Solubility	Easily soluble in dilute hydrochloric acid and formic acid, soluble in water, insoluble in ethanol, benzene, chloroform and ethyl acetate
Vapor Presure	7.97E-09mmHg at 25°C
Appearance	White to milky white crystalline powder
Color	White to creamy
Merck	14,5464
BRN	2215169
pKa	2.32(at 25℃)
Storage Condition	2-8°C
Stability	Stable. Incompatible with strong oxidizing agents. Light and air sensitive.
Sensitive	Sensitive to light and air
Refractive Index	-12 ° (C=5, 1mol/L H
MDL	MFCD00002598
Physical and Chemical Properties	melting point 295°C specific optical rotation -11.7 ° (c = 5.3, 1N HCl)
Use	An effective drug for the treatment of paralysis of shock, mainly used for Parkinson’s syndrome, etc

59-92-7 – Risk and Safety

Hazard Symbols	Xn – Harmful
Risk Codes	R22 – Harmful if swallowed R36/37/38 – Irritating to eyes, respiratory system and skin. R20/21/22 – Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 – Wear suitable protective clothing. S24/25 – Avoid contact with skin and eyes.
WGK Germany	3
RTECS	AY5600000
FLUKA BRAND F CODES	10-23
TSCA	Yes
HS Code	29225090
Toxicity	LD50 in mice (mg/kg): 3650 ±327 orally, 1140 ±66 i.p., 450 ±42 i.v., >400 s.c.; in male, female rats (mg/kg): >3000, >3000 orally; 624, 663 i.p.; >1500, >1500 s.c. (Clark)

 LevodopaCapsules

This product contains levodopa (C9H11N04) should be 90.0% to 110.0% of the label.

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trait

The content of this product is white or white particles or powder.

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identification

taking an appropriate amount of the contents of this product, the same reaction was shown according to the tests of (1) and (2) under the item of levodopa.take an appropriate amount of the content of this product (about 750mg of levodopa), add 3mol/L hydrochloric acid solution 25ml, shake to dissolve levodopa, filter, to the filtrate, a human ammonia solution was added dropwise to adjust the pH value to 4.0, stirred, and left in the dark for several hours to precipitate levodopa. After filtration, the precipitate was washed with water, and the precipitate was dried at 105°C. The infrared absorption pattern of the precipitate should be consistent with that of the control (Spectrum set 87).

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examination

dissolution dissolution of this product, according to the dissolution and release determination method (General rule 0931 The first method), hydrochloric acid solution (9-100) as the dissolution medium, the speed is rpm, operate according to law, after 30 minutes, take 10ml of solution, filter, take 5ml of filtrate accurately, put it in 50ml measuring flask, dilute to the scale with hydrochloric acid solution (9-1000), shake well, according to the method under the content determination item, from the “ultraviolet-visible spectrophotometry”, according to the law, the dissolution of each particle is calculated. The limit is 80% of the labeled amount and shall be in accordance with the provisions.other requirements shall be in accordance with the relevant provisions under the paragraph of glue (General rule 0103).

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Content determination

take the contents under the difference of loading amount, mix evenly, accurately weigh an appropriate amount (about 30mg equivalent to levodopa), and follow the method under item Levodopa Tablets, from “in 100ml measuring flask”, it is measured and calculated according to law.

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category

Same as levodopa.

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specification

0.25g

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storage

light shielding, sealed storage.

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